PrusaSlicer also has a cut feature that will let you split your files. I use to use Cura but swapped over maybe late last year with my CR10S Pro V2.
Attached are some pictures of me using the cut feature. I demonstrate this by loading in a helmet too big for the print area. I slice it in half, then one of the halves into half again.
I've not used meshmixer or any other softwares for this other than Bambu Studios for the X1C printer. I'm unsure about Prusa but I know on Bambu you can also save the individual slices as their own files which is nice. I don't see why you couldn't on Prusa.