Are you talking about the inside or outside of a part? Please specify, it makes a difference.
Bondo can be tedious (and hazardous without safety equipment) but it's the "go-to" because it is cheap and easily available to most.
If you are looking for an alternative to bondo for the outside of a part, you may want to give Apoxie Sculpt a try, but you'll need to let the material cure overnight before you can sand it etc.
I would not suggest using it to coat the inside of a part for reinforcement- it can get heavy.
If you want a safer alternative for inside reinforcement and don't want to use bondo\rondo\fiberglass, I would say use a two part casting resin like Smooth Cast 320. It mixes easy, 1 to 1 by volume. Slosh it around on the inside and it works just as well.