Well, no, but assuming R2 has control over the targeting systems of the starships he docks with, his aim adjustments on blasters do lead to deaths. And, in aiding a human harm another human, that breaks Asimov's laws, but then, this takes place prior to Asimov's very existence, in another galaxy... Hmm.
Reading the Wookieepedia article, after over 160 years of existence, R2 never actually killed anyone, himself.